Dedoplistskaro region is remarkable for many historical and cultural monuments:

• 5th century Khornabuji Fortress (founded by King Vakhtang Gorgasali). It is located 4 km north from Dedoplistkaro Municipality Centre on steep limestone rocks. Travel from municipality centre to the city-fortress takes 15 minutes by car. It is possible to hike up the fortress on foot. Photo Gallery
• V-VI century St. Elias Church on Mount Elias. It is located 3 km to the south from Dedoplistskaro Municipality centre, on limestone rock of Mount Elias.Travel from municipality centre to Mount Elias takes 10 minutes. It is possible to walk up to the church, which is built in the middle of the rock at a height of 60 m. Photo Gallery 
• The domed Church of the Ascention (X century) near village Ozaani, which is decorated by unique frescoes that date back to X century. The church is located 19 km to the north-east of Dedoplistskaro Municipality center in a broad-leaved forest. Travel from the municipality centre to the church takes 30 minutes. Photo Gallery 
• The domed Church of Seraphoim of Sarov (XVIII) in village Samreklo. The church is located 3 km to the east of the municipality centre. Travel to the church by car takes 10 minutes. Photo Gallery
• Khirsa Monastic Complex (VIII), where the burial place of Stephen of Khirsa (one of the Assyrian Fathers) is located. The monastery is located 25 km to the north of Dedoplistskaro Municipality centre, in the southern part of Alazani Valley, on a hiltop. Travel from municipality centre to the church takes 30 minutes. Photo Gallery
• Dedoplistskaro Cave Complex (X-XI), rock carved temple, which is decorated with frescoe ornaments. The complex is located 20 km to the south of Dedoplistskaro Municipality centre, on Iori plateau. Travel by care takes 30 minutes. It is possible to hike up to the temple by foot.
• Niko Pirosmanashvili State Museum in village Mirzaani (museum is a home to original works by Niko Pirosmani). The museum is 25 km to the north-west from Dedoplistskaro Municipality centre. Travel by car takes 30 minutes. Photo Gallery